Description:
Boost the natural testosterone production. Has anti-estrogenic properties.
Great for post cycle therapy.
Potency: 50mg/tablet.
Appearance: White capsule shaped tablet with round surface.
Packing: 100 tablets
Dosage: 50mg-150mg/day.
Clomiphene citrate is in existence since 1960s, during which period it
was first used to treat cases of oligomenorrhea. Its next usage was its
application to the treatment of anovulation.
Clomiphene citrate is a selective estrogen receptor modulator (SERM)
having an affinity to increase the production of gonadotropins by
controlling hypothalamus. Mainly it is used in female infertility cases
related to ovarian stimulation to reverse oligo ovulation or anovulation
like infertility in polycystic ovary syndrome. It is also used for
ovarian hyper stimulation being a part of in vitro fertilization
process. It inhibits estrogen receptors in hypothalamus resulting into
inhibition of negative feedback of estrogen on production of
gonadotropin.
Clomiphene citrate stimulates hypothalamic pituitary axis. It is found
to be helpful in the treatment of secondary male hypogonadism
conditions. For this particular range of treatment, it is considered as a
better choice than testosterone replacement therapy (TRT) for
convenience purposes. As is in the case of testosterone replacement
therapy in which the size of the testes shrinks considerably, it does
not happen in case of treatment done by Clomiphene citrate in place of
TRT. As is evident, that shrinkage of testes causes decrease in
fertility. So that risk is gone with the usage of Clomiphene citrate.
TRT can lead a man to sterility.
Clomiphene citrate is generally used by male bodybuilders and athletes
who prefer to use anabolic steroids for the purpose of binding the
estrogen receptors in their body. This in turn blocks the effects of
estrogen like gynecomastia. It also helps in restoration of body's
natural production capability of testosterone. Usually it is termed as
'recovery drug' and is taken towards the end of steroid cycle by
athletes and bodybuilders. Clomiphene citrate is an anti estrogen for
attaining improvement in recovery of natural testosterone producing
capacity after a cycle. It is used for improving testosterone production
of endurance athletes. It is also effective in reduction of risk of
gynecomastia during a cycle having usage of aromatizable steroids.
Clomiphen is a triphenylethylene derivative a far relative of
diethylstilbestrol. Clomiphene citrate functions as a selective estrogen
receptor modulator. It inhibits estrogen binding to estrogen receptors
and has mixed agonist and antagonist activity depending on the target
tissue. Commercially clomiphen is available in the market as its
dihydrogen citrate salt known as Clomiphene citrate. It consists of two
stereoisomers - zu-clomiphen (38%) and en-clomiphen (62%). These two
isomers were initially termed as cis-isomer and trans-isomer
respectively. Where the en-clomiphen clears off quickly, the
zu-clomiphen has a significant longer life. These two isomers have mixes
estrogenic and antiestrogenic effects. Zu-clomiphen has higher
estrogenic tendency than en-clomiphen.
Clomiphene citrate gets absorbed by the gastrointestinal tract. First
50% excretion of oral dose of clomiphen occurs in fifth day after its
intake. However the rest takes almost six weeks. In females it works as a
fertility drug and increases the number of eggs released for possible
fertilization thereby increasing the chances of a female getting
pregnant. It is generally administered to women who are not able to
ovulate on regular basis or in those cases where pregnancy has not
occurred for long.
